Thyroid Check-Up: Tests, Ultrasound and Thyroid Conditions
By Dr. Alessio Maiorino, Endocrinologist at Aventino Medical Group, Rome The thyroid is a small gland located in the front of the neck, yet it plays a fundamental role in the balance of the entire body. Through the production of thyroid hormones, it helps regulate metabolism, energy consumption, body temperature, heart rate, and numerous other functions. When the thyroid is overactive, underactive, or presents structural alterations, symptoms can vary widely andβespecially in the early stagesβbe non-specific: fatigue, weight fluctuations, palpitations, nervousness, heat or cold intolerance, mood changes, or sleep disturbances can all have multiple causes. For this reason, when there is a clinical suspicion or risk factors are present, a thyroid check allows for the evaluation of both its function and, when indicated, its structure. What does checking the thyroid mean?Β Thyroid evaluation is not based on a single test. It generally comprises three complementary levels: It is important to understand the difference: blood tests primarily tell us how the thyroid functions, while ultrasound mainly shows us what it looks like. A thyroid can therefore have normal hormone values yet present a nodule on ultrasound; similarly, it may be structurally little altered while functioning too much or too little. 1. The endocrinological consultationΒ The first step is gathering the clinical history. The endocrinologist evaluates the potential presence of symptoms compatible with thyroid dysfunction and takes into consideration certain factors that may increase the likelihood of developing a thyroid condition. These may include: During the consultation, the doctor may also observe and palpate the neck region to assess the size, consistency, and regularity of the thyroid and check for any nodules or enlargements. However, the presence of a single symptom is not sufficient to diagnose a thyroid disease: many disorders commonly attributed to the thyroid can have other causes. 2. Blood tests: what do they measure? TSH: the main indicator of thyroid function TSH (Thyroid Stimulating Hormone) is produced by the pituitary gland and has the task of stimulating the thyroid to produce its own hormones. It is generally the first test used to evaluate thyroid function. In simplified terms: This data must nevertheless be interpreted together with the clinical picture and, when necessary, other thyroid hormones. FT4: Free ThyroxineΒ FT4, or free thyroxine, represents one of the main forms of thyroid hormone present in the blood. The combined interpretation of TSH and FT4 makes it possible to distinguish different conditions: In the presence of a TSH below the reference range, in fact, measuring FT3 as well may be indicated. 3. Thyroid antibodies: anti-TPO and anti-TgΒ Some of the most common thyroid diseases are of autoimmune origin: the immune system produces antibodies directed against components of the gland itself. Anti-Thyroperoxidase Antibodies β Anti-TPO Anti-TPO antibodies are particularly useful when an autoimmune thyroid pathology is suspected. Their positivity is frequently associated with Hashimoto’s autoimmune thyroiditis, one of the main causes of hypothyroidism. However, they may also be present in other autoimmune thyroid conditions and, in some subjects, may test positive without a clinically manifest thyroid dysfunction being present. Anti-Thyroglobulin Antibodies β Anti-Tg Anti-thyroglobulin antibodies (Anti-Tg) represent a further indicator of thyroid autoimmunity and can be present especially in autoimmune thyroiditis. In this case as well, the result must not be interpreted in isolation but alongside TSH, FT4, ultrasound, and the clinical picture. Thyroid antibodies, therefore, are not used to diagnose thyroid cancer: their main task is to contribute to the evaluation of autoimmune pathologies. 4. Thyroid ultrasound: what does it allow us to see? Thyroid ultrasound is a non-invasive, painless examination free of ionizing radiation. The patient is made to lie down with the neck slightly extended. The doctor applies a small amount of gel to the skin and uses an ultrasound probe to observe the gland. The examination makes it possible to evaluate: What happens if a nodule is found? Thyroid nodules are very common, and the majority are benign. The discovery of a nodule therefore does not mean having cancer. However, ultrasound makes it possible to study certain characteristics, including composition, echogenicity, margins, shape, and the potential presence of calcifications or suspicious lymph nodes. Based on ultrasound characteristics and size, the doctor can determine whether monitoring is sufficient or whether it is advisable to proceed with further checks, such as ultrasound-guided thyroid fine-needle aspiration. What diseases can a thyroid check help detect? The check-up can lead to the identification of very diverse conditions: Hypothyroidism In hypothyroidism, the thyroid produces an insufficient quantity of thyroid hormones. It can manifest with: Diagnosis stems primarily from the evaluation of TSH and FT4. There are also subclinical forms, in which TSH is altered while FT4 still remains within reference values. Hashimoto’s Thyroiditis Chronic autoimmune thyroiditis of Hashimoto is a disease in which the immune system reacts against the thyroid. Over time, it can cause a progressive reduction in gland function and thus hypothyroidism. Evaluation may include: Having positive antibodies does not necessarily mean already having hypothyroidism: function and autoimmunity are two linked yet distinct aspects. Hyperthyroidism In hyperthyroidism, the thyroid produces an excessive quantity of thyroid hormones. Among possible symptoms: Tests may highlight reduced TSH, associated in overt forms with an increase in FT4 and/or FT3. Graves-Basedow Disease Graves-Basedow disease is one of the main causes of autoimmune hyperthyroidism. When the clinical and hormonal picture suggests this possibility, specific antibodies directed against the TSH receptor, called TRAb, may be requested. These antibodies are not necessarily part of an initial routine check-up, but are used when it is necessary to investigate the cause of hyperthyroidism. Thyroiditis The thyroid can also be affected by inflammatory processes of varying origins. Some types of thyroiditis may initially provoke the release into the blood of hormones already stored in the gland, resulting in a temporary phase of thyrotoxicosis; subsequently, a phase of reduced thyroid function may appear. The necessary investigations depend on the type of suspected thyroiditis and the clinical history. Goiter Goiter refers to an increase in thyroid dimensions. It can be: The combination of consultation, hormone










